by Bill Roberts - Contrary to what many would expect, this compound is actually only a weak agonist of the androgen receptor (AR), with poor binding. It follows, then, that its value must mostly come from non-AR-mediated effects. It is therefore a Class II steroid. Since it is not very effective in activating ARs, it should be stacked with a Class I steroid that is effective in this regard, such as Primobolan , Deca Durabolin , or trenbolone acetate . There is no point in stacking it with Anadrol®, which has similar activity -- one ought to simply use the more appropriate drug. With testosterone or Deca, Danabol / Dianabol is to be preferred; with Primobolan or trenbolone acetate, Anadrol® is to be preferred (though Danabol / Dianabol is still a good choice) because Anadrol® does not aromatize. For an oral-only cycle -- something I don't recommend -- Anadrol® is the better choice in my opinion for that also, at 150 mg/day (preferably divided to 3 or 6 doses.)
As mentioned above, a person would have to be right on the edge of an estrogen problem anyway for a dosage such as 5 or 10 mg/day to cause an estrogen problem. So the answer would be generally no. But if for example already having small natural gyno, then it might make sense to avoid even very small increases in estrogen such as this would be. But it would not take a full 50 mg of Clomid to counteract 10 mg/day of Dianabol. One Clomid tab the first day, the second day, and then one per every three days (. days 5, 8, and so forth) should be plenty for that.